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Article: The asymmetric synthesis of a biologically active sulphoxide.
- Article from:
- Chemistry and Industry
- Article date:
- August 15, 1994
- Author:
CopyrightCOPYRIGHT 1994 Society of Chemical Industry. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Finding a compound with useful biological activity is, in itself, no mean feat. But working out a cost effective full scale synthesis for it is a difficult task
Many natural or synthetic biologically active compounds contain a sulphoxide functional group. As a result of the tetrahedral geometry of sulphur, sulphoxides can be chiral and frequently only one enantiomer is responsible for the desired biological activity. Sulphoxides are also important as potential metabolites of the corresponding sulphides. Yet, because of the very limited number of practical synthetic methods, the development of enantiomerically pure sulphoxides in the pharmaceutical industry has been ...