|
|
Article: Oxidative stress mediates tau-induced neurodegeneration in Drosophila.(Research article)
- Article from:
- Journal of Clinical Investigation
- Article date:
- January 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 American Society for Clinical Investigation. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
Markers of oxidative damage have been detected in brain tissue from patients with Alzheimer disease (AD) and other neurodegenerative disorders. These findings implicate oxidative injury in the neurodegenerative process, but whether oxidative stress is a cause or a consequence of neurotoxicity remains unclear. We used a Drosophila model of human tauopathies to investigate the role of oxidative stress in neurodegeneration. Genetic and pharmacological manipulation of antioxidant defense mechanisms significantly modified neurodegeneration in our model, suggesting that oxidative stress plays a causal role in neurotoxicity. We demonstrate that the JNK signaling pathway is ...
Related newspaper, magazine, and journal articles:
|
|
Article: Oxidative stress regulation by ATM gene required ...
Angiogenesis Weekly;
December 17, 2004 ;
696 words
... ... NewsRx.net) -- Oxidative stress regulation by the ... activating a key cell-cycle checkpoint in response ... telomeric instability or oxidative stress. "Mutational inactivation ... mediated inhibition of oxidative stress." Ito and colleagues ...
|
|