Article: Hydroxyurea therapy: improving the lives of patients with sickle cell disease.

Sickle cell disease (SCD) is an autosomal recessive inherited blood disorder that most commonly affects over 90,000 African-Americans in the United States, as well as Hispanics, and people of Middle-eastern ancestry or from the Mediterranean region (Food & Drug Administration, 1998; Roberts, 2003). For a child to inherit sickle cell disease, both parents must be carriers, or one parent has the disease and the other is a carrier. If both parents are carriers, there is a 1 in 4 chance (25%) a pregnancy will produce a child with sickle cell disease. If one parent has the disease and the other is a carrier, there is a 1 in 2 chance (50%) a pregnancy will produce a child with ...

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