Article: The case against ergocalciferol (vitamin D2) as a vitamin supplement.(Recently Published Abstracts)(Author abstract)

Supplemental vitamin D is available in 2 distinct forms: ergocalciferol (vitamin D(2)) and cholecalciferol (vitamin D(3)). Pharmacopoeias have officially regarded these 2 forms as equivalent and interchangeable, yet this presumption of equivalence is based on studies of rickets prevention in infants conducted 70 y ago. The emergence of 25-hydroxyvitamin D as a measure of vitamin D status provides an objective, quantitative measure of the biological response to vitamin D administration. As a result, vitamin D(3) has proven to be the more potent form of vitamin D in all primate species, including humans. Despite an emerging body of evidence suggesting several plausible ...

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