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Article: Mast cells dysregulate apoptotic and cell cycle genes in mucosal squamous cell carcinoma.(Primary research)(Report)
- Article from:
- Cancer Cell International
- Article date:
- December 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Abstract
Background: Mucosal squamous cell carcinoma of the head and neck is a disease of high mortality and morbidity. Interactions between the squamous cell carcinoma and the host's local immunity, and how the latter contributes to the biological behavior of the tumor are unclear. In vivo studies have demonstrated sequential mast cell infiltration and degranulation during squamous cell carcinogenesis. The degree of mast cell activation correlates closely with distinct phases of hyperkeratosis, dysplasia, carcinoma in-situ and invasive carcinoma. However, the role of mast cells in carcinogenesis is unclear.
Aim: This study explores the effects of mast ...