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Article: Patterns of C4d staining in patients with lupus nephritis.(Clinical report)
- Article from:
- Journal of Applied Research
- Article date:
- June 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 Therapeutic Solutions LLC. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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ABSTRACT
Background: C4d, a cleavage product of the activated complement component C4, has attained considerable significance in the last few years for its role in helping elucidate the pathophysiology of renal allograft rejection. This investigation attempts to study the patterns of C4d deposition in native kidneys of patients with lupus nephritis.
Methods: Renal biopsies from 16 patients with lupus nephritis were reviewed for C4d deposition in the glomeruli and peritubular capillaries. Renal involvement in these patients was classified histopathologically according to World Health Organization classification as class II (4 cases), class III (3 cases), ...