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Article: Genetics of host response in leprosy.
- Article from:
- Leprosy Review
- Article date:
- September 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 British Leprosy Relief Association. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Summary In this review, we discuss recently accumulated data, analysing genetic influence on leprosy outcome. Most leprosy-related epidemiological studies are based on the comparison of frequencies of genetic markers in case-control designs using candidate genes, mainly on immunological pathways. Genomic scans using family-based designs also identified some chromosome regions to be tested for association with leprosy. The results have suggested that different genes are implicated in resistance/susceptibility to leprosy, such as tumour necrosis factor-alpha (TNF[alpha]), interleukin (IL)-10, vitamin D receptor (VDR), and parkin, although some of the results obtained in ...