Article: Ramelteon is effective for some insomnia patients.(Psychosomatic Medicine)

ORLANDO -- Ramelteon is effective for a subset of patients with insomnia, according to a presentation at a psychopharmacology congress sponsored by the Neuroscience Education Institute. In addition, because the agent works on melatonin receptors, a potential off-label use is for patients with shift-work disorder.

Ramelteon (Rozerem, Takeda Pharmaceuticals) targets the melatonin receptors MT1 and MT2. The agent is approximately 10 times more potent than melatonin. Other approved drugs promote sleep by increasing [gamma]-aminobutyric acid (GABA), which is normally released by the suprachiasmatic nucleus in the brain.

"Ramelteon is a very interesting drug. It is the first ...

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