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Article: Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines.(Research article)
- Article from:
- Journal of Clinical Investigation
- Article date:
- March 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 American Society for Clinical Investigation. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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We previously found that low shear stress (LSS) induces atherosclerotic plaques in mice with increased lipid and matrix metalloproteinase content and decreased vascular smooth muscle and collagen content. Here, we evaluated the role of chemokines in this process, using an extravascular device inducing regions of LSS, high shear stress, and oscillatory shear stress (OSS) in the carotid artery. One week of shear stress alterations induced expression of IFN-[gamma]-inducible protein-10 (IP-10) exclusively in the LSS region, whereas monocyte chemoattractant protein-1 (MCP-1) and the mouse homolog of growth-regulated oncogene [alpha] (GRO-[alpha]) were equally upregulated in ...
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