Article: Acute systemic disseminated intravascular coagulation: managing a complex medical condition: in patients with major trauma, DIC approximately doubles the mortality rate. In those with sepsis, 30% to 50% develop DIC. The chance that you will encounter this coagulation disorder during clinical practice is quite high.(Disease/Disorder overview)

Acute systemic disseminated intravascular coagulation (DIC) is a complex, acquired, life-threatening coagulation disorder. Its pathophysiology involves uncontrolled intravascular activation of coagulation with secondary fibrinolysis and inevitable consumption of procoagulants and platelets (see Figure 1). (1) In the United States in 1994, there were approximately 18,000 cases of DIC. (1) DIC is not a primary disease; it always occurs secondary to an underlying disorder and may have a broad spectrum of clinical manifestations and multiple etiologies. Because the disease comprises both bleeding and thrombotic events, diagnosis and therapy can be extremely challenging. ...

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