Article: Leishmaniasis: early diagnosis is key: a patient presents with nasal congestion, a history of nosebleed, and painful lesions on his body and in his mouth. What questions should you ask to ensure that you make an accurate diagnosis?(Disease/Disorder overview)(Cover story)

Leishmaniasis is a complex disease distinguished by a variable set of clinical signs and symptoms. It can manifest in a self-limited, cutaneous form or as a life-threatening systemic infection. Historically difficult and painful to treat, this zoonotic infection is caused by a protozoan parasite of the Leishmania species. It is transmitted from the vertebrate reservoir to humans by way of sand flies--insects of the genera Phlebotomus and Lutzomyia (see Figure 1, page 48). Sand flies are 2 mm long and recognizable by their hopping movement and wing position--a nearly erect V-configuration over the body--and breed in feces and areas where there is organic waste. (1,2)

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