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Article: Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications.(Review)
- Article from:
- Molecular Cancer
- Article date:
- April 2, 2007
- Author:
CopyrightCOPYRIGHT 2007 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Minal Vaish (corresponding author) [1]
Background
Gurdon first introduced the concept of stemness state of the cells while successfully achieving the generation of all cell lineages of a living tadpole after transferring the nuclei from intestinal epithelial cells of feeding Xenopus tadpoles to activated enucleated eggs [1, 2]. These types of cells were later on characterized as indispensable entities, identified in multicellular organisms. The stem cell phenotype is contributed by the unique features that include (1) self-renewal which means that after cell division, one of the daughter cells must have the same genetic material as that of ...
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Article: Stem cells could determine how long we live.
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... ... to show that by making stem cells more hardy we can extend ... team tested bone marrow stem cells from various mice strains ... have a gene involved in DNA repair," said Hartmut Geiger ... idea that DNA damage in stem cells is the key to aging is ...
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