Article: Salicylates may cause diarrhea in ulcerative colitis patients.(Digestive Disorders)

FORT LAUDERDALE, FLA. -- About 10% of patients with ulcerative colitis who are taking 5-aminosalicylic acid medications develop worsening diarrhea that may be linked to these drugs.

"Continued treatment with a salicylate in a patient who isn't responding can be worse than useless, because 5-ASA [5-aminosalicylic acid] can trigger diarrhea in some patients," Dr. Raymond Sandier said in an interview at an international colorectal disease symposium sponsored by the Cleveland Clinic Florida.

Many patients with ulcerative colitis who are receiving ineffective treatment with a salicylate also take an antidiarrheal drug, as well as other motility-inhibiting ...

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