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Article: Resistance to dihydroartemisinin.(Letter to the editor)
- Article from:
- Emerging Infectious Diseases
- Article date:
- May 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 U.S. National Center for Infectious Diseases. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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To the Editor: The title of the letter by Cojean et al. (1) is misleading. The data presented essentially point to an absence of in vitro resistance to dihydroartemisinin (dhART) in the panel of African isolates studied, with 1 of 397 isolates having an elevated 50% inhibitory concentration ([IC.sub.50]) for dhART. The S769N PfATPase6 mutation associated with in vitro resistance to artemether (2) was observed in 1 isolate. This mutant isolate had a low [IC.sub.50] for dhART, but its [IC.sub.50] for artemether has not been tested. Since the relationship between in vitro susceptibility to artemether and dhART is still uncertain (3), these data do not disprove the association ...
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Article: French Antilles and French Guiana
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