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Article: The effects of polychlorinated biphenyl on circulating leptin and thyroid hormone status in Sprague-Dawley rats, Rattus norvegicus (1).
- Article from:
- The Ohio Journal of Science
- Article date:
- April 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 Ohio Academy of Science. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Abstract. Polychlorinated biphenyls (PCB) are persistent environmental chemicals that are known thyroid hormone disrupters. Frequently the disruption of one endocrine axis and the timing of the disruption have an impact on other interdependent hormonal responses. Although the mechanisms for the interdependency of thyroid hormones and leptin have not been fully characterized, both are linked to development and regulation of metabolism. Furthermore, PCB accumulation in depot fat could potentially alter leptin production. In the present study 15-and 30-day-old Sprague-Dawley rats were exposed gestationally and lactationally to 1.25 ppm of Aroclor 1254[R], a mixture of 52 PCB ...
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