Article: Labopharm Falls 50 Percent On Second FDA Approvable Letter.

Byline: Jim Shrine, Staff Writer

Labopharm Inc. lost more than half its value Friday after suffering a second setback in its plan to get FDA approval for a once-daily formulation of the analgesic tramadol.

The FDA sent Labopharm a second approvable letter on its new drug application, this one saying the Laval, Quebec-based company failed to demonstrate efficacy due to faulty statistical methodology. Labopharm shares (NASDAQ:DDSS) fell 51.4 percent Friday, or $3.24, to close at $3.07.

The first approvable letter from the FDA came in late September. Labopharm in December said it submitted a complete response that included additional analysis of ...

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