Article: HPLC columns thin down, speed up, and get simpler. (high performance liquid chromatography)(includes related article)

In analytical high performance liquid chromatography (HPLC), the separation columns are changing faster and more dramatically than the rest of the instrument.

New columns with smaller internal diameters (IDs), shorter lengths, and names like "micro-bore," "narrowbore," "micro LC," and "fast LC" are being combined with improved specialty phases, cartridge column devices, and packing materials to expand researchers' capabilities with their HPLC systems.

Microbore columns were first introduced more than 10 years ago, but failed to take hold due to few applications and "even fewer reasons for changing away from conventional systems," says Ronald Majors, a ...

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