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Article: hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.(Research)(Clinical report)
- Article from:
- Molecular Cancer
- Article date:
- June 5, 2007
- Author:
CopyrightCOPYRIGHT 2007 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Mohamed M Desouki [1]; Joseph Geradts [2]; Beatrice Milon [3]; Renty B Franklin [3]; Leslie C Costello (corresponding author) [3]
Background
It has long been established that the normal human prostate gland has the major function and capability of accumulating uniquely high levels of zinc; generally about ten-fold greater than other soft tissues. This capability resides within the glandular secretory epithelial cells of the peripheral zone, which is the major site of origin of most prostate malignancy. Over fifty years of clinical studies have consistently demonstrated that prostate cancer tissue samples consistently contain about 65% less ...
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