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Article: Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans.(Research)
- Article from:
- Journal of Translational Medicine
- Article date:
- July 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Johann Zdolsek (corresponding author) [1]; John W Eaton [2]; Liping Tang (corresponding author) [3]
Background
Implanted devices are increasingly important in the practice of medicine. In an NIH news release dated January 5
th
2000, it was estimated that 8 to 10 percent of the U. S. population currently have permanent medical implants [1]. Although most implant materials are inert, non-immunogenic and non-toxic, devices made of such materials often trigger a variety of adverse reactions. These include surface-mediated thrombosis associated with blood contact surfaces [2], complement activation induced by haemodialysis membranes [3], ...
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