Article: Answering your questions; normal range for anion gap.(Tips from the clinical experts)(Interview)(Column)

Q What is the normal range for anion gap with the formula Na-(Cl+CO2)? With the formula (Na+K)- (Cl+CO2)? Which one should be used?

A The anion gap is defined as the difference between the major measured cation, sodium, and the major measured anions, chloride, and bicarbonate. The anion gap is usually calculated as [N[a.sup.+]-(C[l.sup.-] + HC[O.sub.3.sup.-])]. Other cations present in blood but not normally included in the anion gap calculation include potassium, calcium, magnesium, and IgG. Likewise, there are a number of anions present in blood that are not included in the calculation. These include sulfate, phosphate, and most plasma proteins. In plasma, ...

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