Article: Threshold Pharmaceuticals Initiates Phase 1 Clinical Trial Evaluating TH-302 in Patients With Solid Tumors.

REDWOOD CITY, Calif., July 26 /PRNewswire-FirstCall/ -- Threshold Pharmaceuticals, Inc. , today announced that it has initiated a Phase 1 clinical trial evaluating the safety of TH-302, the Company's first hypoxia-activated prodrug (HAP), in patients with advanced solid tumors.

"TH-302 is a novel cancer therapeutic specifically activated under the low oxygen or "hypoxic" conditions typical of solid tumor cancer cells," said Barry Selick, Ph.D., Threshold's chief executive officer. "Hypoxic tumor cells typically evade traditional anti-cancer drugs that target rapidly dividing cells, ultimately leading to drug resistance, relapse, and metastasis. If TH- 302 can ...

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