Article: Avian Pathol: Inactivated North American and European H5N2 avian influenza virus vaccines protect chickens from Asian H5N1 high-pathogenicity avian influenza virus.(Reprint)(Brief article)(Clinical report)

High-pathogenicity (HP) avian influenza (AI) virus of the H5N1 subtype has caused an unprecedented epizootic in birds within 9 Asian countries/regions since it was first reported in 1996. Vaccination has emerged as a tool for use in managing the infection in view of future eradication. This study was undertaken to determine whether 2 divergent H5N2 commercial vaccine strains, one based on a European and the other a North American low-pathogenicity AI virus, could protect chickens against a recent Asian H5N1 HPAI virus. The North American and European vaccine viruses had 84% and 91% deduced amino acid sequence similarity to the HA1 segment of hemagglutinin protein of ...

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