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Article: Copper deficiency, lead, and paraoxonase: Li et al. respond.(Correspondence)
- Article from:
- Environmental Health Perspectives
- Article date:
- July 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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doi: 10.1289/ehp.10151R
We appreciate the opportunity to discuss the issue raised by Klevay in his letter. Klevay suggested that the decrease of PON1 activity in lead workers, as we reported in our article (Li et al. 2006), might be due to copper deficiency induced by lead intoxication. Because the scope of our study did not include the interaction between lead and copper, we did not measure plasma copper level, ceruloplasmin, or superoxide dismutase (SOD) activity in our cohort. Therefore, it is not possible to test Klevay's hypothesis at this point.
Although animal studies have shown that lead ingestion caused a decrease in blood copper level in cattle ...