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Article: Serious skin disorders and coxibs.
- Article from:
- Bandolier
- Article date:
- September 1, 2006
CopyrightCOPYRIGHT 2006 Bandolier Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are closely related severe acute life-threatening, drug-induced skin disorders, with mortality rates of 10-30%. The background rate in developed countries is of the order of 2 cases per million per year.
These are rare events, though, and pose a problem for calculation of event rates because individual studies tend to have few events. For instance, a study in England identified only four cases of SJS related to coxibs [1]. A study from the US [2] had 123 cases, allowing some calculations of rates.
Study
The FDA adverse event reporting database was searched for cases of SJS and ...
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