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Article: For nausea at end of life, think mechanistically.(Geriatric Medicine)(haloperidol)
- Article from:
- Family Practice News
- Article date:
- August 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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DALLAS -- Haloperidol is, perhaps surprisingly to many, the drug of choice for nausea and vomiting caused by stimulation of the chemoreceptor trigger zone--the No. 1 mechanism for nausea in patients nearing the end of life, Dr. Steven Pantilat said at the annual meeting of the Society of Hospital Medicine.
"Haloperidol is the most potent dopamine-2 antagonist at the chemoreceptor trigger zone. We don't think of it that way. We don't think of it for this purpose. But it actually is a terrific drug, and it's the one we use now as our first-line agent," said Dr. Pantilat, director of the palliative care program at the University of California, San Francisco.
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