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Article: Design, development and in vitro evaluation of sennosides tablets containing pectin HPMC for colonic drug delivery.(Research Paper)(hydroxypropylmethylcellulose)(Report)
- Article from:
- Indian Journal of Pharmaceutical Sciences
- Article date:
- May 1, 2007
- Author:
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Byline: Munira. Momin, K. Pundarikakshudu
The purpose of the present investigation was to achieve colon specific delivery of sennosides using the polysaccharide pectin as a compression-coating agent. In this study, pectin along with hydroxypropylmethylcellulose was used for compression coating of the core tablets of calcium sennoside. Drug dissolution and erosion studies were carried out in pH 1.2 and phosphate buffer pH 7.4 using a pectinolytic enzyme. The system was designed based on the gastrointestinal transit time concept, assuming colon arrival time to be 6 h. It was found that pectin alone was not sufficient to protect the core tablets during entire gastrointestinal ...