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Article: Small animal optical imaging: seeing beyond the visible with infrared dyes.(Instruments & Systems)
- Article from:
- Bioscience Technology
- Article date:
- August 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 Advantage Business Media. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Optical imaging offers the potential for non-invasive study of molecular targets inside the body of the living animal. This technology has been used to follow the progression of disease, the effects of drug candidates on target pathology, the pharmacokinetic behavior of drug candidates, and the development of biomarkers indicative of disease and treatment outcomes. Currently, the three major types of labels used in optical imaging are bioluminescence, fluorescent proteins, and fluorescent dyes or nanoparticles. Bioluminescence and fluorescent proteins require engineering of cell lines or transgenic animals that carry the appropriate gene. Because fluorescent dyes do not ...