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Article: Alterations by indomethacin in proinflammatory consequences of salivary gland cytosolic phospholipase [A.sub.2] activation by porphyromonas gingivalis: role of leptin.(Clinical report)
- Article from:
- Journal of Applied Research
- Article date:
- March 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 Therapeutic Solutions LLC. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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ABSTRACT
In this study, we report on the alterations by cyclooxygenase inhibitor, indomethacin, in the generation of proinflammatory lipid mediators in sublingual salivary gland acinar cells as a consequence of cytosolic phospholipase [A.sub.2] (cPL[A.sub.2]) activation by the lipopolysaccharide (LPS) of a periodontopathic Porphyromonas gingivalis, and assess the role of leptin in the process. We show that indomethacin while not affecting the LPS-induced enhancement in cPL[A.sub.2]-catalyzed arachidonic acid release, caused inhibition in prostaglandin [E.sub.2] (PG[E.sub.2]) production, up-regulation in apoptosis and platelet activating factor (PAF) generation, ...