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Article: Designing clinical trials to evaluate mucus clearance therapy.(Clinical report)
- Article from:
- Respiratory Care
- Article date:
- October 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 Daedalus Enterprises, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Introduction
In Vitro Testing
Animal and Tissue Studies
Clinical Testing
Whom to Study and When
Choosing Outcomes or End Points
Clinical Outcome Measures for Short-Term Studies
Pulmonary Function Changes
Imaging Studies
Volume and Color of Expectorated Sputum
Sputum Inflammatory Mediators
Clinical Outcome Measures for Long-Term Studies
Decline in Pulmonary Function
Exercise Capacity
Dyspnea
Quality-of-Life Scores
Days in Hospital, Days of Additional Therapy
Summary
Mucoactive therapy is meant to improve quality of life by making it easier to breathe and reducing the need for hospitalization and antibiotic therapy. There are a ...
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