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Article: Combined pantethine and probucol therapy for Japanese patients with nonalcoholic steatohepatitis.(Recent Abstracts)(Brief article)(Clinical report)
- Article from:
- Alternative Medicine Review
- Article date:
- September 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 Thorne Research Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Aims: To evaluate the efficacy and mechanism of combined pantethine and probucol therapy in Japanese patients with non-alcoholic steatohepatitis (NASH), liver function, serum cytokines, serum adiponectin and liver biopsy findings were investigated. Methods: Sixteen patients with NASH and hyperlipidemia were treated with pantethine (600 rag/ day) and probucol (500 mg/day) for 48 weeks. Results: The mean pretreatment aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were 66 IU/L and 113 IU/L, respectively, which showed a significant decrease with treatment to 33 IU/L and 51 IU/L (P
Hepatol Res 2007 Jul 4; [Epub ahead of ...
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... ... according to Dr. McPherson, this may not necessarily be detrimental. "The lower HDL cholesterol levels associated with probucol therapy are not in and of themselves evidence of increased atherosclerotic risk," said Dr. McPherson. "In fact, our findings ...
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