Article: Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil.

Article: A phase I dose-finding study using an innovative sequential ...
Advances in Gastrointestinal Cancer;  September 1, 2007 ;     700+ words ... ... innovative sequential biweekly schedule of irinotecan followed 24 hours later by capecitabine ... C, Hartmann J et al. Capecitabine plus irinotecan versus 5-FU/irinotecan [+ or -] celecoxib in first line treatment of metastatic colorectal ...

Article: Irinotecan
Gale Encyclopedia of Cancer;      700+ words ...Irinotecan Definition Irinotecan is a drug used to treat certain types of cancer. Irinotecan, also known as CPT-11, is available under the trade name Camptosar, and may also be referred to as irinotecan hydrochloride or camptothecin-11 ...

Article: Celecoxib demonstrates benefit in preventing premalignant ...
Formulary;  November 1, 2006 ;     700+ words ... ... to 1 recent trial. In a second study of celecoxib use and adenomas, treatment with celecoxib 401) mg/d markedly lowered the incidence ... first trial, the Adenoma Prevention with Celecoxib (APC) randomized, placebo-controlled ...

Article: Celecoxib concentration predicts decrease in prostaglandin ...
BMC Cancer;  February 11, 2008 ;     700+ words ... ... focused on pharmacologic agents such as celecoxib, a clinically available medication which ... and epidemiologic studies suggest that celecoxib is effective both in preventing and in ... found that women who had used 200 mg celecoxib daily for 2 years or longer were 83 ...

Article: Celecoxib: A COX-2 inhibitor for the treatment of ...
Formulary;  May 1, 1999 ;     700+ words ...ABSTRACT Celecoxib (Celebrex), a nonsteroidal antiinflammatory ... by the FDA. By not inhibiting COX-1, celecoxib is expected to have fewer gastrointestinal (GI) and platelet effects. Celecoxib, which has a sulfonamide component to its ...

Article: Celecoxib shows potential to prevent colon ...
Internal Medicine News;  May 15, 2006 ;     700+ words ... ... controlled trials support the potential of celecoxib (Celebrex) to prevent colon cancer ... was 61 years. The study was funded by celecoxib's manufacturer, Pfizer Inc. A total ... receive a once-daily dose of 400 mg of celecoxib; 628 participants received a placebo ...

Article: Celecoxib backed for juvenile rheumatoid arthritis.(News)
Family Practice News;  December 15, 2006 ;     700+ words ... ... nearly unanimous support for approving celecoxib as a treatment for juvenile rheumatoid ... vote that the risk-benefit ratio of celecoxib was "adequate" to support its approval ... comparing naproxen (15 mg/kg daily) with celecoxib (6 mg/kg or 12 mg/kg daily). The ...