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Article: cis sequence effects on gene expression.(Research article)
- Article from:
- BMC Genomics
- Article date:
- August 29, 2007
- Author:
CopyrightCOPYRIGHT 2007 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Andrew W Bergen (corresponding author) [1,2]; Andrea Baccarelli [3,4]; Timothy K McDaniel [5]; Kenneth Kuhn [5]; Ruth Pfeiffer [1]; Jerry Kakol [5]; Patrick Bender [6]; Kevin Jacobs [1,7]; Bernice Packer [1,7,8]; Stephen J Chanock [1,7]; Meredith Yeager [1,7,8]
Background
Among heritable factors that influence phenotypic expression are sequence polymorphisms in genic regions that affect gene expression rather than protein structure [1, 2]. The influence of sequence variation linked to the gene sequence on the regulation of gene expression (
cis
sequence effects) has been studied experimentally in
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