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Article: Prediction of potential drug targets based on simple sequence properties.(Research article)
- Article from:
- BMC Bioinformatics
- Article date:
- September 20, 2007
- Author:
CopyrightCOPYRIGHT 2007 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Qingliang Li [1,2]; Luhua Lai (corresponding author) [1,2]
Background
Although great efforts have been exerted on drug research and development during the past decades, only about 500 drug targets have been identified for clinically using drugs to date[1]. Recently, this number has been revised to be 324[2], which indicates that current pharmaceutical industry actually relies on only a small pool of drug targets, compared to the large number of proteins available in human genome[3]. On the other hand, a significant number of drugs failed in the pipeline of modern drug discovery can be attributed to the wrong drug target definition at the ...
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