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Article: Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice.(Research article)(Report)
- Article from:
- Journal of Clinical Investigation
- Article date:
- November 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 American Society for Clinical Investigation. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of which contribute to aortic dilatation. This study demonstrates that mast cells, key participants in human allergic immunity, participate in AAA pathogenesis in mice. Mast cells were found to accumulate in murine AAA lesions. Mast cell-deficient [Kit.sup.W-sh]/[Kit.sup.W-sh] mice failed to develop AAA elicited by elastase perfusion or periaortic chemical injury. [Kit.sup.W-sh]/[Kit.sup.W-sh] mice had reduced aortic expansion and internal elastic lamina ...