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Article: Potential complications associated with steroid use in the middle and inner ear.
- Article from:
- Ear, Nose and Throat Journal
- Article date:
- November 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 Vendome Group LLC. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Glucocorticoids have been used to treat disorders such as sudden sensorineural hearing loss, autoimmune hearing loss, Meniere's disease, and hearing loss secondary to trauma, viral insult, and idiopathic causes. When used to treat disorders of the inner ear, steroids have traditionally been administered systemically. However, it has been postulated that the steroid levels achieved in the inner ear with systemic administration are not consistent because of the presence of the blood-labyrinth barrier. (1) This can lead to potentially suboptimal therapeutic concentrations and subsequent treatment failure.
Another concern with the systemic administration of steroids ...