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Article: Aspirin + celecoxib may protect against ulcers.(Gastroenterology)(Report)
- Article from:
- Internal Medicine News
- Article date:
- November 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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LOS ANGELES -- Coadministration of daily low-dose aspirin plus celecoxib for 1 week resulted in fewer endoscopically confirmed gastric and/or duodenal ulcers, compared with coadministration with naproxen, Dr. Jay L. Goldstein said at the annual Digestive Disease Week.
Dr. Goldstein and associates at the University of Illinois, Chicago, randomized 661 patients aged 50-75 years in a 2:2:1 fashion into one of three treatment arms after baseline endoscopy: celecoxib 200 mg once daily plus aspirin 81 mg daily (celecoxib group), naproxen 500 mg b.i.d. plus aspirin 81 mg daily (naproxen group), or placebo plus aspirin 81 mg daily (placebo group). Patients took the drugs ...