Article: Aspirin + celecoxib may protect against ulcers.(Gastroenterology)(Report)

LOS ANGELES -- Coadministration of daily low-dose aspirin plus celecoxib for 1 week resulted in fewer endoscopically confirmed gastric and/or duodenal ulcers, compared with coadministration with naproxen, Dr. Jay L. Goldstein said at the annual Digestive Disease Week.

Dr. Goldstein and associates at the University of Illinois, Chicago, randomized 661 patients aged 50-75 years in a 2:2:1 fashion into one of three treatment arms after baseline endoscopy: celecoxib 200 mg once daily plus aspirin 81 mg daily (celecoxib group), naproxen 500 mg b.i.d. plus aspirin 81 mg daily (naproxen group), or placebo plus aspirin 81 mg daily (placebo group). Patients took the drugs ...

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