Article: Study of molecular mechanisms of pro-apoptotic activity of NCX 4040, a novel nitric oxide-releasing aspirin, in colon cancer cell lines.(Research)

Authors: Anna Tesei [1]; Marco Rosetti [1]; Paola Ulivi [1]; Francesco Fabbri [1]; Laura Medri [2]; Ivan Vannini [1]; Manlio Bolla [3]; Dino Amadori [1]; Wainer Zoli (corresponding author) [1]

Background

Nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDS), which consist of a traditional NSAID linked to an -NO 2 moiety via a molecular spacer, represent a promising class of compounds. These drugs were developed to overcome gastrointestinal and renal toxicities, the main limitations in the long-term use of traditional NSAIDs as chemoprotective agents against colon cancer. The rationale behind NO-NSAID development was based on the ...

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