Article: Basal ganglia abnormalities seen in neuropsychiatric lupus.(Neuropsychiatric Medicine)

BIRMINGHAM, ENGLAND -- Metabolic changes in the basal ganglia that can be detected with magnetic resonance spectroscopy may precede irreversible changes from neuropsychiatric lupus, according to a pilot study.

"Why look at basal ganglia? They are highly prone to hypoxic damage and have recently been linked with the frontal lobe regarding cognitive function," Dr. Pamela L. Peterson said at the annual meeting of the British Society for Rheumatology. In Parkinson disease "and other diseases, there is increasing recognition of the role of basal ganglia."

There are at least four circuits that link the basal ganglia to the cerebral cortex. Although less common, movement ...

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