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Article: Age at developmental cortical injury differentially Alters corpus callosum volume in the rat.(Research article)
- Article from:
- BMC Neuroscience
- Article date:
- November 12, 2007
- Author:
CopyrightCOPYRIGHT 2007 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Steven W Threlkeld [1]; Glenn D Rosen [2,3]; R Holly Fitch (corresponding author) [1]
Background
Freezing lesions to the developing cortical plate result in a cascade of local and distal anatomical and physiological changes, including hyperexcitability around the point of disruption, deviation of axonal projections from targets in the hemisphere contralateral to the pathology, and changes in thalamo-cortical connectivity [2, 3, 4]. Freezing lesions induced on postnatal day 1 (P1) and P3 in rats resemble human four-layer microgyria (as seen postmortem in dyslexics; [9, 10]). Moreover, the presence of microgyria has been associated with rapid ...
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