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Article: Albumin microspheres of fluticasone propionate inclusion complexes for pulmonary delivery.(Proceedings of the Symposium on Advances in Pulmonary and Nasal Drug Delivery, October 2007, Mumbai)(Author abstract)(Clinical report)
- Article from:
- Indian Journal of Pharmaceutical Sciences
- Article date:
- September 1, 2007
- Author:
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Byline: A. Lohade, D. Singh, J. Parmar, D. Hegde, M. Menon, P. Soni, A. Samad, R. Gaikwad
Fluticasone propionate (FP) is a lipophilic drug used to control inflammation in patients with asthma, allergic rhinitis and chronic obstructive pulmonary disease (COPD)[sup] [1] . The poor aqueous solubility (
Material and Methods
Equilibrium solubility of FP (Sun Pharmaceutical Industries Ltd, India) was determined in aqueous HP[sz]CD (Gangawal Chemicals, India) solution at 37[sup]o[+ or -]2[sup]o for 7 d, and solubility constant was calculated from phase-solubility diagram. HP[sz]CD inclusion complex of FP was prepared by the spray drying and freeze drying techniques ...