Article: Baicalein inhibits IL-1[beta]- and TNF-[alpha]-induced inflammatory cytokine production from human mast cells via regulation of the NF-[kappa]B pathway.(Research)

Authors: Chia-Jung Hsieh [1]; Kenton Hall [1]; Tuanzhu Ha [2]; Chuanfu Li [2]; Guha Krishnaswamy [1]; David S Chi (corresponding author) [1]

Background

Human mast cells are multifunctional cells involved in numerous immune and inflammatory reactions [1, 2]. Mast cells have been implicated in acute and chronic inflammatory responses and in many diseases characterized by inflammation [3]. The fact that mast cells accumulate at sites of inflammation, such as the nasal mucosa of patients with allergic rhinitis [4], the lung smooth muscle of patients with asthma [5], the skin of patients with urticaria [6], and the joints of patients with arthritis [7], illustrates the ...

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