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Article: SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance.(Research article)(Scavenger receptor class B1)(Clinical report)
- Article from:
- Journal of Clinical Investigation
- Article date:
- January 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 American Society for Clinical Investigation. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Septic shock results from an uncontrolled inflammatory response, mediated primarily by LPS. Cholesterol transport plays an important role in the host response to LPS, as LPS is neutralized by lipoproteins and adrenal cholesterol uptake is required for antiinflammatory glucocorticoid synthesis. In this study, we show that scavenger receptor B-I (SR-BI), an HDL receptor that mediates HDL cholesterol ester uptake into cells, is required for the normal antiinflammatory response to LPS-induced endotoxic shock. Despite elevated plasma HDL levels, SR-BI--null mice displayed an uncontrollable inflammatory cytokine response and a markedly higher lethality rate than control mice in ...
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Article: NPC1L1 and SR-BI are Involved in Intestinal ...
Lipids;
May 1, 2008 ;
700+ words
... ... cholesterol transporters (NPC1L1, SR-BI) to the absorption processes, using ... diameter), mainly due to NPC1L1 and SR-BI involvement. In addition, bile acids ... protein expression of NPC1L1, but not of SR-BI. In conclusion, bile acids present ...
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