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Article: Engineering stem cell fate.(Tissue Engineering)
- Article from:
- Science & Medicine
- Article date:
- February 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 Science & Medicine. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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A hurdle in the development of many cell-based therapies is securing a reliable source of cells. The choice of cell source is dictated primarily by the specific application. For example, tissue-engineered skin constructs incorporating allogeneic keratinocytes and fibroblasts, used to treat burns and diabetic foot ulcers, have proved to be quite suitable due to the temporary nature of the graft, which is replaced by host cells. Most host tissues, however, are not endowed with robust regenerative capacity, and thus, the search for cells with regenerative potential has become a driving concern for many investigators.
The isolation of embryonic stem cells from mice ...