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Article: Reduced body weight is a common effect of gene knockout in mice.(Correspondence)
- Article from:
- BMC Genetics
- Article date:
- January 8, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Danielle R Reed (corresponding author) [1]; Maureen P Lawler [1]; Michael G Tordoff [1]
Background
The mechanisms underlying the control of body weight are undoubtedly complex but there have been few attempts to assess exactly how complex. In order to gauge the number of pieces in the body weight puzzle, we attempted to estimate the number of genes involved. One way to do this is to study the effects on body weight of knocking out all mouse genes, one by one. Something similar has been done in yeast and worms but for the mouse this is probably years and perhaps decades away [1, 2]. Therefore, we focused on the information that was available: ...
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