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Article: Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.(Research article)
- Article from:
- BMC Genetics
- Article date:
- March 22, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Pushplata Prasad [1]; KM Prasanna Kumar [2]; AC Ammini [3]; Arvind Gupta [4]; Rajeev Gupta [5]; BK Thelma (corresponding author) [1]
Background
A large number of genetic association studies for unraveling the genetic basis of renal disease in diabetes have been carried out using polymorphisms in candidate genes from various postulated biochemical and metabolic pathways. These include renin-angiotensin-aldosterone system (RAAS), protein kinase C (PKC)-polyol, advanced glycation end (AGE) product, hexosamine and oxidative stress. However the results are confusing and identification of genetic susceptibility to chronic renal insufficiency ...
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