Article: SEATTLE-AREA COMPANIES TRY TO DELIVER ON PROMISE OF RNAI TARGETED GENETICS PLANS CLINICAL TRIALS IN '09.(Business)

Byline: JOSEPH TARTAKOFF P-I reporter

In Huntington's disease, which afflicts about one in 10,000 Americans, one gene is defective - making it difficult for patients to walk, talk or swallow.

So, if there was a way to "silence" that one gene there could potentially be a cure.

That's the promise of RNA interference technology, and it has three Seattle-area companies trying to find a way to make it deliver.

"There has been no other technology that has been capable of shutting off aberrant genes," said H. Stewart Parker, the chief executive of Seattle-based Targeted Genetics.

On Monday, her company said it would accelerate its ...

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