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Article: A formal synthesis of (+)-muricatacin from L-tartaric acid.(GENERAL NOTES)(Report)
- Article from:
- The Texas Journal of Science
- Article date:
- November 1, 2007
- Author:
CopyrightCOPYRIGHT 2007 Texas Academy of Science. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Muricatacin (1) is an acetogenin that displays cytotoxic activity towards certain tumor cell lines found in humans (Figure 1). This lipid-soluble class of anticancer drug was first isolated from the seeds of the Soursop tree (Annona muricata) and has received considerable attention in recent years. This paper describes a formal synthesis of (+)-muricatacin (1) using tartaric acid (2) as a chiral controller. The key step in this synthesis is the formation of butenolide 3 by way of intramolecular cyclization of 4a while under acidic conditions. The synthesis of 5S-(1S,2-dihydroxy-ethyl)-dihydro-furan-2-one (5), a formal precursor to 1 required six steps with an overall yield ...
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Article: 6 000 t/a tartaric acid unit established in ...
China Chemical Reporter;
March 26, 2004 ;
525 words
...A 6 000 t/a tartaric acid unit invested by Hangzhou LinAn ... production with qualified products. Tartaric acid is a widely used organic acid ... Recently the global demand for the tartaric acid increased year by year, and the ...
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