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Article: In vitro cytogenetic effects of Andrographis paniculata (kalmegh) on arsenic.(Report)
- Article from:
- Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
- Article date:
- March 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 Urban & Fischer Verlag. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Introduction
Arsenical compounds are environmental toxins with multiple effects in animal and human populations. The US Environmental Protection Agency has placed arsenic at the top of its Superfund contamination list (Hei and Filipic, 2004). Epidemiological data have shown that chronic levels of exposure to arsenite are associated with the cancer of skin, lungs bladder, and kidney (Mo et al., 2006). Accumulated evidence has shown that arsenite-induced cytogenetic alterations are associated with its carcinogenicity. Arsenical compounds are potent clastogens in many cell types inducing chromosomal aberrations, sister chromatid exchanges (SCEs), cell cycle arrest, ...