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Article: CDKN1C /p57.sup.kip2 .sup.is a candidate tumor suppressor gene in human breast cancer.(Research article)
- Article from:
- BMC Cancer
- Article date:
- March 6, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Pamela S Larson (equal contributor) [1]; Benjamin L Schlechter (equal contributor) [2]; Chia-Lin King [2]; Qiong Yang [3]; Chelsea N Glass [4]; Charline Mack [1]; Robert Pistey [1]; Antonio de las Morenas [1]; Carol L Rosenberg (corresponding author) [1,2]
Background
Cyclin-dependent kinases (CDK) are a family of enzymes that govern the mammalian cell cycle (among other functions) and whose aberrant upregulation can lead to oncogenic effects. Consequently, proteins that negatively regulate CDKs, cyclin-dependent kinase inhibitors (CDKNs), are strong candidate tumor suppressor genes. CDKNs fall into two families. The CDKN1 family contains ...
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