Article: Increased endothelin-1 levels of BAL fluid in patients with Behcet's disease.(Clinical Study)(bronchoalveolar lavage)(Report)

Objective and background. Pulmonary aneurysms and thrombosis constitute a significant cause of morbidity and mortality in Behcet's disease (BD). Various factors have been studied to explore the pathogenesis of vascular involvement in BD. As endothelin (ET) is known for its potent vasoconstrictor and proinflammatory properties, we supposed that it is involved during the inflammatory process of BD pulmonary vasculitis. Methods. To investigate the role of ET in BD, ET-1 concentrations were measured in bronchoalveolar lavage fluid (BALF) of 18 nonsmoking BD patients with pulmonary manifestations and 12 control subjects. Immunoreactivity of ET-1 was also evaluated in alveolar ...

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